Chemical and Biological Sciences

Associate Professor (2023 to 2026), Department of Chemical and Biological Sciences, S.N. Bose National Centre for Basic Sciences, Kolkata, India. Previously served as Tenured Associate Professor (2023) and Assistant Professor (2018 to 2023) at Ashoka University, Sonipat, India. Completed postdoctoral research at Columbia University (2016 to 2018) and the Max Planck Institute of Biochemistry, Munich (2013 to 2015). Earned a Ph.D. from the Indian Institute of Chemical Biology (2008 to 2012), Kolkata, and an M.Sc. in Chemistry from the University of Burdwan. Research focuses on single-molecule biophysics, integrating physics, chemistry, and biology to investigate biomolecular mechanisms.

A. Develop cutting-edge single-molecule technologies (e.g., magnetic tweezers, fluorescence-force spectroscopy) to probe biomolecular dynamics with nanometer precision and long-time stability.

B. Investigate chaperone biology, uncovering how mechanical forces regulate protein folding, misfolding, and cellular proteostasis.

C. Elucidate mechanochemical signaling, focusing on how force transduction modulates protein interactions and cellular decision-making.

D. Explore cancer biology through mechanobiology and AI-driven approaches to understand tumor heterogeneity, cancer stem cells, and therapeutic vulnerabilities.

Integrate physics, chemistry, and biology with computational tools to uncover fundamental principles governing complex biological systems.

1. Priyadarshi, S., ...... & Haldar, S.* (2025) OncoMark: A high-throughput neural multi-task learning framework for cancer hallmark quantification, Communications Biology (IF: 6).
2. Mistry, A., ........ & Haldar, S.* (2024) Mechanisms of molecular chaperones via single-molecule technologies, Trends in Biochemical Sciences (IF: 14.3).
3. Banerjee, S., ...& Haldar, S.* (2024) Force-regulated chaperone activity, Protein Science (IF: 8).
4. Chaudhuri, D., .... & Haldar, S.* (2023) Chemical chaperones and mechanical roles, Nanoscale (IF: 8.3).
5. Chakraborty, S., .... & Haldar, S.* (2022) Energy landscapes from single-molecule experiments, Nanoscale (IF: 8.3).
6. Chaudhuri, D., Banerjee, S., Chakraborty, S. & Haldar, S.* (2022) Mechanical role of bacterial chaperones, Biomacromolecules (IF: 7).
7. Eckels, E.C., & Haldar, S.* (2021) Redox-switchable mechanical chaperone DsbA, Chemical Science (IF: 10).
8. Banerjee, S., ... & Haldar, S.* (2021) Single-molecule technologies in cellular biochemistry, Annual Review of Biophysics (IF: 19.8).
9. Alonso-Caballero, A., ..., Haldar, S.. (2020) Protein folding modulates adhesion strategy of Gram-positive pathogens, Nature Chemistry (IF: 24.3).
10. Eckels, E., Haldar, S., ... Fernández, J. (2019) Disulfide bonds: power switches of elastic proteins, Cell Reports (IF: 10).
11. Haldar, S.*, & Fernandez, J. (2017) Mechanical folding by the Trigger Factor chaperone, Nature Communications (IF: 17.7).

https://www.shubhasis-haldar-cmt.com/